2/16/2024 0 Comments Nottingham histologic scoreSimilar content being viewed by othersĪngiogenesis is a critical factor in the development and progression of breast cancers. Our study suggests DCE-MRI can non-invasively assess breast cancer angiogenesis, which could stratify biology and optimize treatments. Several radiomics texture features were also promising for predicting increased MVD (maximum AUC = 0.84, p = 0.002). 1.61, area under the receiver operating characteristic curve = 0.79, p = 0.009) and higher WF (mean: 50.6% vs. Lesions with high MVD levels demonstrated higher peak SER than lesions with low MVD (mean: 1.94 vs. Invasive breast cancer kinetic features (initial peak percent enhancement, signal enhancement ratio, functional tumor volume, and washout fraction ), radiomics features (108 total features reflecting tumor morphology, signal intensity, and texture), and MVD (by histologic CD31 immunostaining) were measured in 27 patients (1/2016–7/2017). We evaluated the association of semi-quantitative kinetic and radiomic breast cancer features on dynamic contrast-enhanced (DCE)-MRI with microvessel density (MVD), a marker for angiogenesis. Angiogenesis is a critical component of breast cancer development, and identification of imaging-based angiogenesis assays has prognostic and treatment implications.
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